Jacqueline Siu
Wellcome Trust Early Career Fellow
Jacqueline is a Wellcome Trust Early Career Fellow in the Coles/ Dendrou Lab at the Kennedy Institute of Rheumatology.
Jacqueline’s research focus is to understand the role of early human B cell response (extrafollicular response) which has a vital role in rapid antibody production. By integrating human challenge models, ex vivo cultures, and single-cell genomics, she aims to address a fundamental immunological question about early human B cells and their impact on long-lived antibodies. Findings may facilitate tailored nextgeneration vaccination and adjuvant strategies to enhance long-term memory responses.
Publications
- Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood. Siu JHY. et al, (2022), Science Immunology
- B cells in human lymphoid structures. Montorsi L., Siu JHY., Spencer J., (2022), Clinical and Experimental Immunology
- T cell allorecognition pathways in solid organ transplantation. Siu JHY. et al, (2018), Frontiers in Immunology
- Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue. Zhao Y.*, Uduman M.*, Siu JHY.*, Tull TJ.* et al, (2018), Nature Communications