Renier van der Hoorn
Renier is a plant biologist interested in understanding the manipulation of plants by microbial plant pathogens.
His research activities also aim at improved recombinant glycoprotein production in plants and pioneering activity-based proteomics in plant science.
Renier was born in Leiden, the Netherlands in 1971 and was fascinated by plant biology from early childhood. He studied chemistry at Leiden University and focused soon on plant molecular biology and biochemistry. After his graduation in 1996, he started his PhD in Molecular Phytopathology (Wageningen University, Prof. Dr. Pierre de Wit), where he worked on the tomato Cf resistance proteins.
He continued working on Cf proteins in Wageningen as a postdoc, and started his own research program by introducing and applying activity-based protein profiling in plants. To further develop the technology he joined the phosphoproteomics group of Dr. Scott Peck for one year (Sainsbury lab, John Innes Centre, Norwich, UK).
He initiated the Plant Chemetics lab in October 2005 at the Max Planck Institutes of Cologne and Dortmund as part of the Chemical Genomics Centre of the Max Planck Society. His research group operated independently from the departments at the Max Planck Institutes while he trained twelve MSc students, nine PhD students, eleven postdocs and over 30 visiting scientists.
In October 2013, he was appointed Associate Professor at the Department of Plant Sciences of the University of Oxford, and elected Tutor in Plant Sciences at Somerville College. His research focuses on the use of chemical proteomics to uncover novel host manipulation mechanisms employed by microbes when colonizing the apoplast.
Selected publications since 2014:
Ilyas, M., Hörger, A. C., Bozkurt, T. O., Van den Burg, H. A., Kaschani, F., Kaiser, M., Belhaj, K., Smoker, M., Joosten, M. H. A. J., Kamoun, S., and Van der Hoorn, R. A. L. (2015) Functional divergence of two secreted immune proteases of tomato. Current Biol. 25, 1-7.
Lu, H., Chandrasekar, B., Oeljeklaus, J., Misas-Villamil, J. C., Wang, Z., Shindo, T., Bogyo, M., Kaiser, M., and Van der Hoorn, R. A. L. (2015) Subfamily-specific probes for Cys proteases display dynamic protease activities during seed germination. Plant Physiol. 168, 1462-1475.
Dong, S., Stam, R., Cano, L. M., Song, J., Sklenar, J., Yoshida, K., Bozkurt, T. O., Oliva, R., Liu, Z., Tian, M., Win, J., Banfield, M. J., Jones, A. M., Van der Hoorn, R. A. L., and Kamoun, S.(2014) Effector specialization in a lineage of the Irish potato famine pathogen. Science 343, 552-555.
Chandrasekar, B., Colby, T., Emon, A. E. K., Jiang, J., Hong, T. N., Villamor, J. G., Harzen, A., Overkleeft, H. S., and Van der Hoorn, R. A. L. (2014) Broad range glycosidase activity profiling. Mol. Cell. Proteomics. 13, 2787-2800.
Sueldo, D., Ahmed, A., Misas-Villamil, J. C., Colby, T., Tameling, W., Joosten, M. H. A. J., andVan der Hoorn, R. A. L. (2014) Dynamic hydrolase activities precede hypersensitive tissue collapse in tomato seedlings. New Phytologist 203, 913-925.