Simon Kyle

Senior Research Fellow; Professor of Experimental and Clinical Sleep Research; Programme Director of The Oxford Online Programme in Sleep Medicine; NIHR Oxford BRC Senior Research Fellow

I have specific research interests in the etiology and management of sleep disturbance and the interaction between sleep disturbance and mental health.


This is a selection of Professor Kyle’s Key Publications. You can review a complete bibliography here.

‘Clinical and cost-effectiveness of nurse-delivered sleep restriction therapy for insomnia in primary care (HABIT): a pragmatic, superiority, open-label, randomised controlled trial’. Kyle SD. et al, (2023), The Lancet

‘The effect of sleep restriction therapy for insomnia on sleep pressure and arousal: a randomized controlled mechanistic trial’. Maurer LF. et al, (2021), Sleep

‘Amygdala responses to negative faces are not associated with depressive symptoms: cross-sectional data from 28,638 individuals in the UK Biobank cohort’. Tamm S. et al, (2022), American Journal of Psychiatry

‘Isolating the role of time in bed restriction in the treatment of insomnia: a randomized, controlled, dismantling trial comparing sleep restriction therapy with time in bed regularization’. Maurer LF. et al, (2020), Sleep, 43

‘The effects of digital cognitive behavioral therapy for insomnia on cognitive function: a randomized controlled trial’. Kyle SD. et al, (2020), Sleep, 43

‘Biological and clinical insights from genetics of insomnia symptoms’. Lane JM. et al, (2019), Nature Genetics, 51, 387 – 393

‘The effect of sleep continuity disruption on multimodal emotion processing and regulation: a laboratory-based, randomized, controlled experiment in good sleepers.’ Reid M. et al, (2022), Journal of Sleep Research

‘The acute effects of sleep restriction therapy for insomnia on circadian timing and vigilance’. Maurer LF. et al, (2020), Journal of Sleep Research

‘Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort (N = 25,758)’. Schiel J. et al, (2022), Biological Psychiatry

‘Associations between insomnia symptoms and functional connectivity in the UK Biobank cohort (n = 29,423)’. Holub F. et al, (2023), J Sleep Res, 32

‘A Randomized, Placebo-Controlled Trial of Online Cognitive Behavioral Therapy for Chronic Insomnia Disorder Delivered via an Automated Media-Rich Web Application’. Espie CA. et al, (2012), Sleep, 35, 769 – 781

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