Professorial Fellow; Professor of Neuroscience
Matthew Wood is Professor of Neuroscience and Associate Head of the Medical Sciences Division (http://www.medsci.ox.ac.uk/support-services/matthew-wood) in the University of Oxford. His laboratory is based in the Department of Paediatrics.
Matthew graduated in Medicine from the University of Cape Town in 1987, working in clinical Neuroscience before gaining a doctorate in Physiological Sciences from the University of Oxford in 1993. His research team works on developing gene therapies for degenerative disorders of the brain and muscles – so-called neuromuscular diseases. This is exemplified by landmark work using small DNA patches called oligonucleotides to correct the genetic abnormalities underlying the fatal childhood muscle disease Duchenne muscular dystrophy
Further information is available at Professor Wood’s page with the Oxford Neuroscience and Department of Paediatrics.
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
Alvarez-Erviti L. et al, (2011), Nat Biotechnol, 29, 341 - 345
Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy.
Winkelsas AM. et al, (2021), Mol Ther Nucleic Acids, 23, 731 - 742
Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-
Tone Y. et al, (2021), Nucleic Acid Ther
Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing.
Hanson B. et al, (2021), RNA Biol, 1 - 15
Molecular and electrophysiological features of spinocerebellar ataxia type seven in induced pluripotent stem cells.
Burman RJ. et al, (2021), PLoS One, 16
Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
Patutina OA. et al, (2020), Proc Natl Acad Sci U S A, 117, 32370 - 32379