Gitalee Sarker

Fulford Junior Research Fellow; Tutor in Medicine, Lady Margaret Hall; Novo Nordisk Postdoctoral Research Fellow

I joined the Domingos group in the Department of Physiology, Anatomy and Genetics at the University of Oxford as a Novo Nordisk postdoctoral fellow in 2019.

My research focuses on the study of neuroimmune mechanisms underlying obesity. I use advanced molecular and genetic technologies along with computational approaches for transcriptomic profiling of sympathetic ganglia and the sympathetic neurons innervating the fat tissue. The aim is to identify the novel cellular and molecular targets that may lead to develop new tissue-specific therapies for obesity.

I completed my Ph.D. in Neuroscience at ETH Zurich in 2018. During my Ph.D., I have investigated the long-term impact of maternal overnutrition on the brain, behaviors, and metabolism. My study reveals that perinatal maternal high fat diet-induced obesogenic and addictive like phenotypes can be conserved across three generations via the paternal lineage and identifies sperm tRNA-derived small RNA as a potential epigenetic mark that partly mediates such abnormal traits to the progeny. Prior to my Ph.D., I attained an MSc in Neuroscience from the University of Bonn, Germany. I also hold a Bachelor in Medicine and Surgery (MBBS) from Dhaka Medical College, Bangladesh.

 

Publications

ILC3s gut rhythm
Journal article
Sarker G. et al, (2020), Nature Immunology

Maternal overnutrition during critical developmental periods leads to different health adversities in the offspring: relevance of obesity, addiction and schizophrenia
Journal article
Sarker G. et al, (2019), Scientific Reports, 9

Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs
Journal article
Sarker G. et al, (2019), Proceedings of the National Academy of Sciences, 116, 10547 - 10556

Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
Journal article
Sarker G. and Peleg-Raibstein D., (2018), Nutrients, 11, 7 - 7

Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition
Journal article
Sarker G. et al, (2018), Translational Psychiatry, 8

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