Fay Probert
Dorothy Hodgkin Career Development Fellow
Fay graduated from Warwick University with a BSc in Mathematics before moving to the Department of Chemistry where she completed an MSc in Mathematical Biology and Biophysical Chemistry.
Since completing her PhD in Analytical Chemical Biology, Fay has worked at Bruker (UK) and the Medical Research Council (Harwell) applying analytical chemistry techniques, with a focus on NMR spectroscopy, to a range of biological and medical research questions. Throughout her postdoctoral career, Fay’s research has focused on using a multidisciplinary combination of analytical chemistry, mathematics, and biology techniques to understand the chemistry of small molecule pathways associated with disease. In particular, Fay is interested in better understanding the chemical processes associated with inflammation in the brain with the aim of improving the diagnosis and treatment of these diseases.
Fay joined the Department of Pharmacology at Oxford in October 2015 as a senior postdoctoral researcher in the Anthony lab managing a small team of metabolomics researchers and leading several projects which aim to develop NMR metabolomics and multivariate statistical methods to better diagnose, monitor, and predict treatment response in inflammatory diseases of the central nervous system. In 2018, Fay was awarded a Junior Research Fellowship at Somerville College, Oxford.
In 2021 Fay was a awarded a Dorothy Hodgkin Career Development Fellowship in the Chemistry Department.
Fay has received research funding from the MS Society, MRC, EPSRC, BSRC, Merck, and Numares AG.
Publications
1. Radford-Smith DE, Anthony DC, Benz F, Grist JT, Lyman M, Miller JJ, Probert F. A multivariate blood metabolite algorithm stably predicts risk and resilience to major depressive disorder in the general population. EBioMedicine. 2023 Jul;93:104643.
2. Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA, Iwamoto Y, Roudko V, Downey J, Chan CT, Huynh P, Janssen H, Ntranos A, Hoffmann JD, Jacob W, Goswami S, Singh S, Leppert D, Kuhle J, Kim-Schulze S, Nahrendorf M, Kleinstiver BP, Probert F, Roussos P, Swirski FK, McAlpine CS. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Immunity. 2023 May 2:S1074-7613(23)00177-2.
3. Schmid AB, Ridgway L, Hailey L, Tachrount M, Probert F, Martin KR, Scott W, Crombez G, Price C, Robinson C, Koushesh S, Ather S, Tampin B, Barbero M, Nanz D, Clare S, Fairbank J, Baskozos G. Factors predicting the transition from acute to persistent pain in people with ‘sciatica’: the FORECAST longitudinal prognostic factor cohort study protocol. BMJ Open. 2023 Apr 5;13(4):e072832.
4. Radford-Smith DE, Yates AG, Rizvi L, Anthony DC, Probert F. HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation. Lipids Health Dis. 2023 Apr 24;22(1):54.
5. Probert F, Gorlova A, Deikin A, Bettendorff L, Veniaminova E, Nedorubov A, Chaprov KD, Ivanova TA, Anthony DC, Strekalova T. In FUS[1-359]-tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome. Biomed Pharmacother. 2022 Dec 156:113986.
6. Yeo T, Bayuangga H, Augusto-Oliveira M, Sealey M, Claridge TDW, Tanner R, Leppert D, Palace J, Kuhle J, Probert F*, Anthony DC. Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model. J Neuroinflammation. 2022 Oct 9;19(1):252.
7. Lennox B, Xiong W, Waters P, Coles A, Jones PB, Yeo T, May JTM, Yeeles K, Anthony D, Probert F. The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis. Mol Psychiatry. 2022 Sep 21. doi: 10.1038/s41380-022-01784-4.
8. Radford-Smith DE, Probert F, Burnet PWJ, Anthony DC. Modifying the maternal microbiota alters the gut-brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9)
9. Probert F*, Yeo T, Zhou Y, Sealey M, Arora S, Palace J, Claridge TDW, Hillenbrand R, Oechtering J, Kuhle J, Leppert D, Anthony DC. Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands. Front Immunol. 2022 Feb 4
10. Radford-Smith DE, Selvaraj EA, Peters R, Orrell M, Bolon J, Anthony DC, Pavlides M, Lynch K, Geremia A, Bailey A, Culver EL, Probert F*. A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis. Liver Int. 2022 Feb 7.
11. Radford-Smith DE, Patel PJ, Irvine KM, Russell A, Siskind D, Anthony DC, Powell EE, Probert F. Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS One. 2022 Jan 6;17(1)
12. Larkin JR, Anthony S, Johanssen VA, Yeo T, Sealey M, Yates AG, Smith CF, Claridge TDW, Nicholson BD, Moreland JA, Gleeson F, Sibson NR, Anthony DC, Probert F*. Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms. Clin Cancer Res. 2022 Jan 4.
13. Portero V, Nicol T, Podliesna S, Marchal GA, Baartscheer A, Casini S, Tadros R, Treur JL, Tanck MWT, Cox IJ, Probert F, Hough TA, Falcone S, Beekman L, Müller-Nurasyid M, Kastenmüller G, Gieger C, Peters A, Kääb S, Sinner MF, Blease A, Verkerk AO, Bezzina CR, Potter PK, Remme CA. Chronically elevated branched chain amino acid levels are pro-arrhythmic. Cardiovasc Res. 2022 Jun 22;118(7):1742-1757.