Elena Seiradake
Fellow & Tutor in Biochemistry; Professor in Molecular Biology
Elena joined the Oxford University Biochemistry Department in 2014 as an independent group leader to study the structure and function of cell surface receptors in neural and vascular development.
A major breakthrough in her laboratory revealed that the adhesion GPCR ‘Latrophilin’ forms large structured assemblies in the presence of two other cell surface receptors ‘FLRT’ and ‘Unc5’. Depending on the cellular context, distinct super-complexes with unique functional properties are formed. Elena’s long-term aim is to understand the functions of distinct receptor-ligand complexes through a detailed knowledge of their structures and signalling properties during neural and vascular development of the brain.
Lab group website: https://www.bioch.ox.ac.uk/research/seiradake
Publications
The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs. Jackson, V, Hermann, J, Tynan, CJ, Rolfe, DJ, Kalli, AC, Duncan, AL, Jones, EY, Sansom, MSP, Martin-Fernandez, ML, Seiradake, E, Chavent, M. October 2020.
Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Del Toro, D, Carrasquero-Ordaz, MA, Chu, A, Ruff, T, Shahin, M, Jackson, VA, Chavent, M, Berbeira-Santana, M, Seyit-Bremer, G, Brignani, S, Kaufmann, R, Lowe, et al. January 2020. In ‘Cell’
Homozygous Missense Variants in NTNG2, Encoding a Presynaptic Netrin-G2 Adhesion Protein, Lead to a Distinct Neurodevelopmental Disorder. Dias, CM, Punetha, J, Zheng, C, Mazaheri, N, Rad, A, Efthymiou, S, Petersen, A, Dehghani, M, Pehlivan, D, Partlow, JN, Posey, JE, Salpietro, V et. al. November 2019, ‘Am J Hum Genet’
Teneurin Structures Are Composed of Ancient Bacterial Protein Domains. Jackson, VA, Busby, JN, Janssen, BJC, Lott, JS, Seiradake, E. January 2019. ‘Front Neurosci’
DIPping into the Fly Visual System. Aksu, M, Seiradake, E. December 2018. ‘Neuron’
Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function. Chavent, M, Karia, D, Kalli, AC, Domański, J, Duncan, AL, Hedger, G, Stansfeld, PJ, Seiradake, E, Jones, EY, Sansom, MSP. July 2018. ‘Structure’