Daniel Anthony
Fellow & Tutor in Medicine; Professor of Experimental Neuropathology
My work centres on inflammatory diseases, and I lead the Experimental Neuropathology Laboratory at the University of Oxford in the Department of Pharmacology.
As a Fellow of Somerville College and an Honorary Professor at the University of Southern Denmark, my research explores the effect of systemic inflammation on the outcome of central nervous system (CNS) injury and disease. I also investigate circulating extracellular vesicles in CNS diseases and the role of cytokine production in neuropsychiatric disorders.
My career started with a Ph.D. from University College London in 1994, followed by a British Biotech Fellowship in Oxford focusing on CNS metalloproteinase expression. Downstream, this research has led to clinical trials with protease inhibitors in inflammatory diseases, including COVID. My work has also identified new biomarkers for disease diagnosis and progression in human and veterinary medicine, using a mix of in vivo and molecular biology, immunohistochemistry, MRI/PET imaging, and metabolomics.
After a Lecturer position in Neurobiology at the University of Southampton, I returned to Oxford in 2004 to further my research on the neurobiology of inflammation. My work is has led to over three hundred publications and patents. I was made Chair in Experimental Neuropathology in 2015 and I was awarded a Fellowship by the British Pharmacological Society in 2020. At Somerville College, my focus is on educating future medical professionals, combining my research insights with teaching.
At Somerville College, I teach physiology and pharmacology to preclinical and graduate entry medical students.
For a full list of publications: https://orcid.org/0000-0003-1380-6655
Publications
The following is a selected list of Professor Anthony’s recent publications. For a complete list, visit https://orcid.org/0000-0003-1380-6655
1. Dunstan IK, McLeod R, Radford-Smith DE, Xiong W, Pate T, Probert F, Anthony DC. Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences. Front Cell Neurosci. 2024 Feb 13;18:1345441. doi: 10.3389/fncel.2024.1345441. eCollection 2024.
2. Xiong W, Anthony DC, Anthony S, Ho TBT, Louis E, Satsangi J, Radford-Smith DE. Sodium fluoride preserves blood metabolite integrity for biomarker discovery in large-scale, multi-site metabolomics investigations. Analyst. 2024 Jan 15. doi: 10.1039/d3an01359f.
3. Trofimov A, Pavlov D, Goswami A, Gorlova A, Chaprov K, Umriukhin A, Kalueff A, Deykin A, Lesch KP, Anthony DC*, Strekalova T. Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS). Brain Behav Immun Health. 2023 Sep 15;33:100686. doi: 10.1016/j.bbih.2023.100686. eCollection 2023 Nov.
4. Pereira PDC, Diniz DG, da Costa ER, Magalhães NGM, da Silva AJF, Leite JGS, Almeida NIP, Cunha KN, de Melo MAD, Vasconcelos PFDC, Diniz JAP, Brites D, Anthony DC, Diniz CWP, Guerreiro-Diniz C. Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents. Front Immunol. 2023 Aug 29;14:1239572. doi: 10.3389/fimmu.2023.1239572.
5. Radford-Smith DE, Anthony DC. Leveraging Health Linkage Data From the UK Biobank-With Great Power Comes Great Responsibility. JAMA Psychiatry. 2023 Aug 23. doi: 10.1001/jamapsychiatry.2023.2966.
6. Bloemendaal M, Veniaminova E, Anthony DC, Gorlova A, Vlaming P, Khairetdinova A, Cespuglio R, Lesch KP, Arias Vasquez A, Strekalova T. Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice. Nutrients. 2023 Jul 6;15(13):3048. doi: 10.3390/nu15133048.
7. Chan KW, Hebert J, Radford-Smith D, Anthony DC, Burnet PWJ. Live or heat-killed probiotic administration reduces anxiety and central cytokine expression in BALB/c mice, but differentially alters brain neurotransmitter gene expression. Chan KW, Hebert J, Radford-Smith D, Anthony DC, Burnet PWJ. Neuropharmacology. 2023 Sep 1;235:109565. doi: 10.1016/j.neuropharm.2023.109565
8. Radford-Smith DE, Anthony DC, Benz F, Grist JT, Lyman M, Miller JJ, Probert F. A multivariate blood metabolite algorithm stably predicts risk and resilience to major depressive disorder in the general population. EBioMedicine. 2023 Jun 14;93:104643. doi: 10.1016/j.ebiom.2023.104643. PMID: 37327674
9. Khan RMN, Ahn YM, Marriner GA, Via LE, D’Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, Dayao E, Piazza MK, Gomez F, Dieckmann W, Herscovitch P, Mason NS, Swenson R, Kiesewetter DO, Backus KM, Geng Y, Raj R, Anthony DC, Flynn JL, Barry CE, Davis BG. Distributable, Metabolic PET Reporting of Tuberculosis. bioRxiv. 2023 Apr 3:2023.04.03.535218. doi: 10.1101/2023.04.03.535218. Preprint. PMID: 37333343
10. Radford-Smith DE, Yates AG, Rizvi L, Anthony DC, Probert F. HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation. Lipids Health Dis. 2023 Apr 24;22(1):54. doi: 10.1186/s12944-023-01817-z.
11. Pate T, Anthony DC, Radford-Smith DE. cFOS expression in the prefrontal cortex correlates with altered cerebral metabolism in developing germ-free mice. Front Mol Neurosci. 2023 Apr 20;16:1155620. doi: 10.3389/fnmol.2023.1155620. eCollection 2023.
12. Radford-Smith DE, Anthony DC. Prebiotic and Probiotic Modulation of the Microbiota-Gut-Brain Axis in Depression. Nutrients. 2023 Apr 13;15(8):1880. doi: 10.3390/nu15081880.
13. Radford-Smith DE, Anthony DC. Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders. Metabolites. 2023 Mar 20;13(3):455. doi: 10.3390/metabo13030455