Fellow & Tutor in Medicine; Professor of Experimental Neuropathology
Daniel Anthony is Professor of Experimental Neuropathology. His research group is located in the Department of Pharmacology.
Daniel joined Somerville and the Department of Pharmacology in 2004 where he established the Experimental Neuropathology Laboratory. The focus of the work of his laboratory is to explore the cross-talk between the brain or spinal cord and the peripheral immune system using a combination of non-invasive imaging, molecular biology and immunochemical techniques. Signals carried between the brain and the peripheral immune system are important in the development of CNS disease, and there is now considerable evidence to support the idea that inappropriate immune system activation contributes, in a deleterious manner, not only to the archetypal inflammatory disease of the brain, multiple sclerosis, but also to acute neurological diseases, such as stroke and head trauma, and to chronic neurodegenerative diseases, such as Alzheimer’s disease, prion disease, and HIV-related dementia.
Laboratory website: http://users.ox.ac.uk/~bioc0541/ENP/Welcome.html
1. Dickens AM, Larkin JR, Davis BG, Griffin JL, Claridge TDW, Sibson NR, Anthony DC. NMR-based metabolomics separates the distinct stages of disease in a chronic relapsing model of multiple sclerosis. Journal of Neuroimmune Pharmacology (2015) 015 Sep;10(3):435-44.
2. Couch Y, Xie Q, Lundberg L, Sharp T, Anthony DC. A model of post-infection fatigue is associated increased TNF and 5-HT2A receptor expression in mice. PlosOne 10(7):e0130643 (2015).
3. Losey P, Ladds E, Laprais M, Guevel B, Burns L, Bordet R, Anthony DC. The role of PPAR activation during the systemic response to brain injury. Journal of Neuroinflammation, 12:99 (2015).
4. Strekalova T, Evans M, Costa-Nunes J, Bachurin S, Yeritsyan N, Couch Y, Steinbusch HMW, Köhler SE, Lesch KP, Anthony DC. Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet. Brain Behavior and Immunity pii: S0889-1591(15)00057-4(2015)
5. Airas L, Dickens AM , PElo P, Marjamäki P, Johansson J, Eskola O, Jones PA, Trigg W, Solin O, Haaparanta-Solin M, Anthony DC, Rinne J. In vivo positron emission tomography imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of Multiple Sclerosis J Nucl Med. 56(2):305-10 (2015).
6. Dickens A, Anthony DC, Deutsch R, Mielke MM, Claridge DW, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, JC McArthur, N. Haughey. CSF Metabolomics Implicate Bioenergetic Adaptation as a Neural Mechanism Regulating Shifts in Cognitive States of HIV-Infected Subjects. AIDS 2015 PMID: 25611149