Angela Vincent
Emeritus Fellow
Professor Vincent’s (FRS FMedSci) major research interest is in the role of autoimmunity in neurological diseases, mainly auto-antibody mediated ion channel and receptor disorders.
These rare conditions are now recognised world-wide, diagnosed with tests she helped to develop, and treated with drugs that reduce the levels of the antibodies, with very good clinical responses.
She was previously honorary consultant in immunology and founded the Oxford Clinical Neuroimmunology service, an international referral centre for the measurement of antibodies in neurological diseases, that she led for 24 years. She was formerly Head of Department of Clinical Neurology (2005-2008), President of the International Society of Neuroimmunology (2001-2004), and an Associate Editor of the journal Brain (2004-2013). She formally retired in 2016 but has continued to publish with collaborators in the UK and abroad (total >400). She has received many national and international awards for her work.
Publications
Selected key publications
Vincent A A. Immunology of acetylcholine receptors in relation to myasthenia gravis. Physiological reviews. 1980 60:756-824.
Vincent A. Unravelling the pathogenesis of myasthenia gravis. Nature reviews Immunology. 2002 2:797-804.
Hoch W, …….Vincent A. 2001. Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7: 365-368.
Vincent A et al. Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia. JAMA Neurol. 2018;75:1519-1527
Vincent A et al. Arthrogryposis Multiplex Congenita with Maternal Autoantibodies Specific for a Fetal Antigen. Lancet. 1995;346:24-5.
Coutinho E…….Vincent A. Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero. Acta Neuropathol. 2017;134:567-583.
Coutinho E……… Vincent A. Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita. Neurol Neuroimmunol Neuroinflamm. 2021;8:e1011.
Vincent A et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004;127:701-712.
Irani SR…………..Vincent A. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain;2010;133:2734-48.