Judith Schweimer

Retaining Fee Lecturer

The main focus of my work is on the influence of monoaminergic neurotransmitters like serotonin (5HT) and dopamine (DA) in relation to psychiatric diseases.

Currently in Trevor Sharp’s group, I am investigating electrical signals of 5HT neurons and cortical interneurons in the normal brain and during pharmacological inhibition of 5HT receptors in combination with neuroanatomical techniques.

Prior to this, I investigated how d-amino acid oxidase (DAO) influences midbrain DA physiology using electrophysiology, microdialysis and HPLC.

In Mark Ungless’s lab at Imperial College, I studied the functional diversity of dorsal raphe 5HT neurons using electrophysiology.

For my PhD with Wolfgang Hauber (University of Stuttgart), I investigated the involvement of the DA innervation of the anterior cingulate cortex on decision-making and learning. I have graduated from the University of Tübingen with an MSc in animal physiology, where I studied the role of the BNST on fear and anxiety behaviour with M. Fendt.

Publications

'Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata.'
Journal article
Heckman PRA. et al, (2018), Brain Struct Funct, 223, 739 - 748

'Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus.'
Journal article
Hescham S. et al, (2016), Brain Struct Funct, 221, 4281 - 4286

'Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo.'
Journal article
Brouard JT. et al, (2015), ACS Chem Neurosci, 6, 1241 - 1247

'Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.'
Journal article
Schweimer JV. et al, (2014), Eur J Neurosci, 40, 2999 - 3009

'D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.'
Journal article
Betts JF. et al, (2014), Front Synaptic Neurosci, 6

Where Next?