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Rajesh Thakker

Professorial Fellow (Somerville); May Professor of Medicine
MA MD Cantab, FRCP, FRCPath, FmedSci, FRS
Nuffield Department of Clinical Medicine

Rajesh Thakker is the May Professor of Medicine at the University of Oxford, and a Fellow of Somerville College, Oxford.  He was previously Professor of Medicine at The Royal Postgraduate Medical School, The Hammersmith Hospital, London, until 1999, when he took up his present position in Oxford.

His main research interests include the molecular basis of disorders of calcium homeostasis.  He has published over 350 articles, and has been the recipient of many prizes which include Young Investigator Award from the ASBMR (USA), the Raymond-Horton Smith Prize (Cambridge University, UK), the Society for Endocrinology (UK) medal, the European Journal of Endocrinology Prize (EFES), the Graham Bull Prize from the Royal College of Physicians (UK), the Parathyroid Medal from the Fondazione Raffaella Becagli (F.I.R.M.O.), the Jack W. Coburn Endowed Lectureship from the American Society of Nephrology, and the Louis V Avioli Founder’s Award from the American Society for Bone and Mineral Research (USA).  In addition, he has served on the MRC Physiological Medicine and Infections Grants Committee (1994-1997), the MRC Clinical Training and Career Development Panel (1997-2000), the MRC Physiological Medicine and Infections Board (2000-2005), as Secretary to the Forum on Academic Medicine for the Royal College of Physicians (UK) and the Academy of Medical Royal Colleges (2002-2005), and on the Council for the Society for Endocrinology (2003-2006). He has been Chairman of the National Institute of Health Research (NIHR) / MRC Efficacy and Mechanisms Evaluations (EME) Board since 2008. He was elected Fellow of the Royal Society (FRS) in 2014.

Examples of recent publications:

Publications
  • 1.Walls GV, Lemos MC, Javid M, Bazan-Peregrino M, Jayabalan J, Reed AA, Harding B, Tyler DJ, Stuckey DJ, Piret S, Christie PT, Ansorge O, Clarke K, Seymour LW, Thakker RV (2012). MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas. Cancer Research, 72: 1-9.
  • 2.Nesbit MA, Hannan FM, Howles SA, Babinsky VN, Head RA, Cranston T, Rust N, Hobbs MR, Heath H III, Thakker RV (2013). Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia. New England Journal of Medicine 368: 2476-86.
  • 3.Nesbit MA, Hannan FM, Howles SA, Reed AAC, Cranston T, Thakker CE, Gregory L, Rimmer AJ, Rust N, Graham U, Morrison P, Hunter SJ, Whyte MP, McVean G, Buck D, Thakker RV (2013). Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3. Nature Genetics, 45: 93-97.
  • 4.Gorvin CM, Wilmer MJ, Piret SE, Harding B, van den Heuvel LP, Wrong O, Jat PS, Lippiat JD, Levtchenko EN, Thakker RV (2013). Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent's disease patients. Proceedings of the National Academy of Sciences, 110: 7014-7019.
  • 5.Newey P, Gorvin C, Cleland S, Willberg C, Bridge M, Azharuddin M, Drummond R, van der Merwe P, Klenerman P, Bountra C, Thakker RV (2013). Mutant prolactin receptor and familial hyperprolactinemia. New England Journal of Medicine, 369: 2012-2020.

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