Elena Seiradake
Fellow & Tutor in Biochemistry; Professor in Molecular Biology
Elena joined the Oxford University Biochemistry Department in 2014 as an independent group leader to study the structure and function of cell surface receptors in neural and vascular development.
‘Understanding how cells form tissues is important, because failure leads to developmental diseases and cancers. Specialised proteins are found at the surfaces of cells and direct their movements as tissues grow. My lab uses a range of cutting-edge techniques to understand how this works, especially X-ray crystallography, electron microscopy, cell biology assays, confocal and super resolution microscopy.’
Learn more: http://seiradake.web.ox.ac.uk
Publications
Selected publications below – full list available here.
1. Akkermans O, Delloye-Bourgeois O, Peregrina O, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, McCubbin P, Comoletti D, Owens R, Robinson CV, Castellani V*, del Toro D*, Seiradake E*
GPC3-Unc5D complex structure and role in cell migration.
Cell, 2022
2. Chu T, Zheng-Gerard C, Huang K, Chang Y, Chen Y, I K, Lo Y, Chiang N, Chen H, Stacey M, Gordon
S,Tseng W, Sun C, Wu Y, Pan Y, Huang C, Lin C, Chen T, Antonelou M, Henderson S, Salama A, Seiradake E*, Lin H*
GPR97-mediated PAR2 transactivation via a mPR3- associated macromolecular complex induces inamma tory activation of human neutrophils.
Nature Commun, 2022
3. Jackson V., Hermann J., Tynan C.J., Rolfe D.J., Corey R.A., Duncan A.L., Noriega M., Chu A., Kalli A.C., Jones E.Y., Sansom M.S.P., Martin-Fernandez M.L*, Seiradake E*, Chavent M*.
The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs.
Structure 2022
4. del Toro D, Carrasquero-Ordaz M, Chu A, Ruff T, Shahin M, Jackson VA, Chavent M, Berbeira-Santana M, Seyit-Bremer G, Brignani S, Kaufmann R, Lowe E, Klein R*, Seiradake E*.
Structural basis of Teneurin-Latrophilin interaction in repulsive guidance of migrating neurons.
Cell, 2020
5. Jackson VA*, Meijer DH, Carrasquero MA, van Bezouwen LS, Lowe ED, Kleanthous C, Janssen BJC,
Seiradake E*.
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Nat Commun 2018
6. Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MSP, Robinson CV, Klein R, Seiradake E*.
Super-complexes of adhesion GPCRs and neural guidance receptors.
Nat Commun 2016